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Clinical, Genetic, and Radiological Features of Extrapyramidal Movement Disorders in Mitochondrial Disease JAMA Neurol 73:668-674, Martikainen, M.H.,et al, 2016 See this aricle in Pubmed Article Abstract Dystonia, often associated with Leigh syndrome, was the most common extrapyramidal movement disorder among pediatric patients with mitochondrial disease. Parkinsonism was the most prevalent extrapyramidal movement disorder in adults and was commonly associated with POLG mutations: dystonia was predominantly associated with mitochondrial DNA mutations. These findings may help direct genetic screening in a busy neurology outpatient setting.

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(click to filter results - removes previous filter) basal ganglia,lesion,bilateral children chorea dystonia Leigh's disease mitochondrial disease movement disorder movement disorder,extrapyramidal MRI,abnormal Parkinson disease POLG1 gene restless leg syndrome

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